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Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant medication used to treat sleepiness due to narcolepsy, shift work sleep disorder, and obstructive sleep apnea. Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant medication used to treat sleepiness due to narcolepsy, shift work sleep disorder, and obstructive sleep apnea. Fgf19 is a hormone that acts directly on the liver to suppress expression of cyp7a1, the key enzyme that catalyses the first and rate-limiting step in the pathway. Fgf19 is a hormone that acts directly on the liver to suppress expression of cyp7a1, the key enzyme that catalyses the first and rate-limiting step in the pathway. Nirmatrelvir; Ritonavir: (Major) Concurrent administration of modafinil with ritonavir may result in elevated plasma concentrations of modafinil and decreased concentrations of ritonavir. 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