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This activity requires intracellular conversion of aciclovir by viral thymidine kinase to the monophosphate with subsequent conversion by cellular enzymes to the diphosphate and the active triphosphate. This activity requires intracellular conversion of aciclovir by viral thymidine kinase to the monophosphate with subsequent conversion by cellular enzymes to the diphosphate and the active triphosphate. In Trazodone and Melatonin interaction, the former is a serotonin modulator while the latter belongs to the drug class herbals for neurology and psychiatry. In Trazodone and Melatonin interaction, the former is a serotonin modulator while the latter belongs to the drug class herbals for neurology and psychiatry. Although PharmaciesReview makes reasonable efforts to verify publicly available information and to obtain reliable content from third parties, PharmaciesReview does not guarantee the accuracy of or endorse the information or opinions given by any third party content provider. 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